About
Alyssa Jayne Milano is an accomplished American actress and activist. She gained initial fame as Samantha Micelli in the sitcom "Who's the Boss?" and later became known for her roles in television series like "Melrose Place," "Charmed," and "Mistresses." Milano has also appeared in "My Name Is Earl," "Wet Hot American Summer: Ten Years Later," and "Insatiable," showcasing her versatility as an actress. As an activist, she played a prominent role in the #MeToo movement in October 2017. She has also performed on Broadway, replacing Roxie Hart in "Chicago", performing her own songs.
Career Timeline
Who's the Boss? Role
Milano gains fame as Samantha Micelli in the sitcom *Who's the Boss?*.
Melrose Place Appearance
She makes an appearance on Melrose Place
Charmed Stardom
Milano stars in *Charmed*, solidifying her status as a television actress.
Mistresses Role
Milano stars in *Mistresses*, continuing her television career.
#MeToo Activism
Milano becomes a prominent voice in the #MeToo movement, using her platform for advocacy.
Active Actress and Activist
Milano continues to act and advocate for social causes, remaining a public figure.
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Last updated: February 25, 2026